Welcome to The Rand Lab at Brown University

Our Research:

 

We are interested in understanding how natural selection acts on genes and genomes. A major focus of the lab is to study the mitochondrial genome and its interactions with the nuclear genome, and how this interaction influences animal performance, evolutionary fitness, and aging. A second major interest is how thermal selection influences the genetic composition of populations. The goals of our work are to identify the genetic interactions that allow organisms to adapt to environmental heterogeneity.

Research Foci:

 

Mitochondrial Evolution using Drosophila:

  • Molecular Evolution

  • Mito-Nuclear coevolution and its fitness consequences

  • Aging

 

Ecological Genomics:

  • Northern Accorn Barnacle as a system to understand ecological heterogenety 

Recent Highlighted Research

The Philosophical Transactions of the Royal Society

Mitonuclear conflict and cooperation govern the integration of genotypes, phenotypes and environments. Rand and Mossman 2019 (Paper)

The Proceedings of the National Academy of Sciences

Footprints of natural selection at the mannose-6-phosphate isomerase locus in barnacles. Nunez et al. 2020 (Paper)

Laboratory News

Joaquin Nunez has defended his dissertation

Congratulations to Dr. Nunez!

Dr. Spierer awarded a 2020 Brown University Library Innovation Prize

Drawing on the rising importance of rigor and reproducibility of research, the Brown University Library announces up to $750 in prizes for a graduate student or undergraduate student publication, capstone paper, and/or thesis/dissertation or digital project incorporating innovation in rigor and transparency, in any field of research. $250 will be awarded for one project each from humanities, behavioral and social sciences, and life and physical sciences. The Carney Institute for Brain Science announces a parallel prize but independent undergraduate prize up to $750 for a capstone paper or thesis, within the general area of brain science, incorporating innovation in reproducibility.

Dr. Santiago awarded a Contribution to Community Life Award

Read more here, Graduate Student Contribution to Community Life Award Recipients:

https://www.brown.edu/about/administration/vp-campus-life/content/2020-0

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Recent Publications by Lab Members - Since 2015

February 25, 2020

Footprints of natural selection at the mannose-6-phosphate isomerase locus in barnacles

Proceedings of the National Academy of Sciences

By Joaquin C. B. Nunez, Patrick A. Flight, Kimberly B. Neil, Stephen Rong, Leif A. Eriksson, David A. Ferranti, Magnus Alm Rosenblad, Anders Blomberg, and David M. Rand

January 01, 2020

Mitonuclear conflict and cooperation govern the integration of genotypes, phenotypes and environments

The Philosophical Transactions of the Royal Society

by David M Rand and Jim A Mossman

December 01, 2019

Mitochondrial genomic variation drives differential nuclear gene expression in discrete regions of Drosophila gene and protein interaction networks

BMC genomics

by Jim A Mossman, Leann M Biancani, David M Rand

February 11, 2019

Mitochondrial DNA fitness depends on nuclear genetic background in Drosophila

in G3: Genes, Genomes, Genetics

Jim A Mossman, Y Ge Jennifer, Freddy Navarro, David M Rand

February 27, 2019

Age of both parents influences reproduction and egg dumping behavior in Drosophila melanogaster

in Journal of Heredity

Jim A Mossman, Russyan Mark S Mabeza, Emma Blake, Neha Mehta, David M Rand

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