Welcome to The Rand Lab at Brown University

Our Research:

 

We are interested in understanding how natural selection acts on genes and genomes. A major focus of the lab is to study the mitochondrial genome and its interactions with the nuclear genome, and how this interaction influences animal performance, evolutionary fitness, and aging. A second major interest is how thermal selection influences the genetic composition of populations. The goals of our work are to identify the genetic interactions that allow organisms to adapt to environmental heterogeneity.

Research Foci:

 

Mitochondrial Evolution using Drosophila:

  • Molecular Evolution

  • Mito-Nuclear coevolution and its fitness consequences

  • Aging

 

Ecological Genomics:

  • Northern Accorn Barnacle as a system to understand ecological heterogenety 

Recent Highlighted Research

The Philosophical Transactions of the Royal Society

Mitonuclear conflict and cooperation govern the integration of genotypes, phenotypes and environments. Rand and Mossman 2019 (Paper)

The Proceedings of the National Academy of Sciences

New barnacle paper coming soon!

Sierra Harken at the UTRA showcase 2018

Rand Lab undergraduate Sierra Harken showcases her microscopy work on D. melanogaster

David Ferranti at the UTRA showcase 2018

Rand Lab undergraduate David Ferranti showcases his work on ecological genomics of the northern accord barnacle S. balanoides

Ian Light at the UTRA showcase 2018

Rand Lab undergraduate Ian Light showcases his work on altitude adaptation and physiology in D. melanogaster

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Recent Publications by Lab Members - Since 2015

January 01, 2020

Mitonuclear conflict and cooperation govern the integration of genotypes, phenotypes and environments

The Philosophical Transactions of the Royal Society

by David M Rand and Jim A Mossman

December 01, 2019

Mitochondrial genomic variation drives differential nuclear gene expression in discrete regions of Drosophila gene and protein interaction networks

BMC genomics

by Jim A Mossman, Leann M Biancani, David M Rand

February 11, 2019

Mitochondrial DNA fitness depends on nuclear genetic background in Drosophila

in G3: Genes, Genomes, Genetics

Jim A Mossman, Y Ge Jennifer, Freddy Navarro, David M Rand

February 27, 2019

Age of both parents influences reproduction and egg dumping behavior in Drosophila melanogaster

in Journal of Heredity

Jim A Mossman, Russyan Mark S Mabeza, Emma Blake, Neha Mehta, David M Rand

January 01, 2019

Age Dependent Dysfunction of Mitochondrial and ROS Metabolism Induced by Mitonuclear Mismatch

in: Frontiers in genetics

Nicolas Pichaud, Roxanne Bérubé, Geneviève Côté, Claude Belzile, France Dufresne, Geneviève Morrow, Robert M Tanguay, David M Rand, Pierre U Blier

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Laboratory News